Granulopoietic effects of human bone marrow fibroblastic cells and abnormalities in the "granulopoietic microenvironment"

Granulopoietic effects of human bone marrow fibroblastic cells and abnormalities in the "granulopoietic microenvironment".

The in vitro granulopoietic effects of adherent bone marrow fibroblastic cells (FC) were studied in normal humans and in patients with acute myelogenous leukemia (AML) and myeloproliferative disorders (MPD). To determine their influence on granulopoiesis, we established FC in liquid-phase cultures, overlaid the adherent FC with normal bone marrow cells in agar, and subsequently measured the gro...

Modulatory effects of Schistosoma mansoni infection on bone marrow granulopoietic and erythropoietic activity in mice.

Bone marrow (BM) cells from BALB/c mice infected with mixed-sex Schistosoma mansoni cercariae were assessed for their capacity to form in vitro colony forming units of erythroid (CFU-e) and granulocyte/macrophage (CFU-c) cells. At four weeks after infection, substantial BM commitment to granulopoiesis was noted by an increase in CFU-c, with no changes in CFU-e. Elevated marrow granulopoietic ac...

Alcohol Suppresses the Granulopoietic

Interacting cell populations affecting granulopoietic colony formation by normal and leukemic human marrow cells.

Effect of hypertransfusion on bone marrow regeneration in sublethally irradiated mice. I. enhanced granulopoietic recovery.

Hypertransfusion can enhance recovery from neutropenia in certain clinical and experimental situations. We have studied the pattern of myeloid recovery in mice hypertransfused after receiving 350 rads whole body irradiation. Both hypertransfused and control groups showed the degenerative phase, abortive rise, and regenerative phase that has been described following sublethal irradiation. The bl...